The purpose of this study was to design matrix tablets of Paracetamol to overcome its side effects and to increase its bioavailability. Carnuba Wax and Bees Wax were used in matrix tablets at various concentrations for sustained drug delivery. Compression and flow properties of powder mixtures were tested before tablets were compressed by direct compression method. Weight variation, diameter and thickness, hardness, tensile strength, friability % and disintegration time of tablets were tested for their physical characterization. Determination method of drug in dissolution mediums was validated through spectroscopic method. All formulations met compendial requirements and any chemical interaction between drug and tablet excipients was not detected. It was observed that waxy tablets released drug faster than polymer based tablets. Waxy tablets generally displayed diffusionally controlled drug release.
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